Streptomycin is a protein synthesis inhibitor. It binds to the small S12 rRNA of the 30S subunit of the bacterial ribosome, interfering with the binding of formyl-methionyl-tRNA to the 30S subunit.^[3]This leads to codon misreading, eventual inhibition of protein synthesis and ultimately death of microbial cells through mechanisms that are still not understood. Speculation on this mechanism indicates that the binding of the molecule to the 30S subunit interferes with 50S subunit association with the mRNA strand. This results in an unstable ribosomal-mRNA complex, leading to a frameshift mutation and defective protein synthesis; leading to cell death.^[4]Humans have structurally different ribosomes from bacteria, thereby allowing the selectivity of this antibiotic for bacteria. At low concentrations, however, Streptomycin only inhibits growth of the bacteria by inducing prokaryotic ribosomes to misread mRNA.^[5]Streptomycin is an antibiotic that inhibits both Gram-positive and Gram-negative bacteria,^[6]and is therefore a useful broad-spectrum antibiotic.

· Shijiazhuang Pharm-Chem Technology Co.,Ltd. is an integrated industrial company specialized in pharmaceutical raw materials, medicine preparations and related medical devices.

Veterinary medicines division composes of two veterinary medicines GMP factories, currently has 10 production lines more than 100 formulations varieties. Main productions are as follows: liquid injection, oral solution, poultry medicine, Livestock medicines, premix and water soluble powder, animal tablets, disinfectant, active pharmaceutical ingredient and traditional Chinese medicine extracts, etc., the annual output of small- volume injection is 150 million (2-10ml), large capacity injection 50 million bottles (50-500ml), premixes (soluble powder) 20 million bags, disinfectant 500 million bottles.

Our company always adheres to the tenet that quality is the basis of survival and innovation is the source of development. We are actively pioneering in pharmaceuticals and medicines all the time. In accordance with the requirements of modern management, we establish and implant quality management system, and acts according to the GMP standards strictly. Our company has established close cooperation with China Agricultural University, Shenyang Pharmaceutical University, Huazhong Agricultural University and many other research institutions, constantly develop new products and improve quality and efficacy at the same time through the application of new technology in order to ensure our company's products in the market leading level.